Annuaire IPHC

DSA | Ingénierie Moléculaire Appliquée à l’Analyse (LIMAA) » Group members » Permanent staff » Aline NONAT

Aline NONAT

Dernière mise à jour : vendredi 26 juin 2015, par Aline NONAT

Academic organism : CNRS

Phone : +33 (0)3 68 85 27 41

Fax : +33 (0)3 68 85 27 25

E-mail :

Express biography

  • Since October 2010 : CNRS researcher, Institut Pluridisciplinaire Hubert Curien (UMR 7178), Laboratoire d’Analyses Appliquées à l’Imagerie (LIMAA), group of Dr Loïc Charbonnière (Strasbourg, France).
  • 2009-2010 : Temporary assistant professor, Molecular Chemistry Institute (ICMUB), University of Burgundy, in the group of Pr Franck Denat (Dijon, FRANCE).
  • 2007-2009 : Academic post-doc (IRCSET fellowship) Supramolecular & Medicinal Chemistry Research Group, Trinity College, in the group of Pr Thorfinnur Gunnlaugsson (Dublin, Ireland)
  • 2004-2007 : PhD thesis in Bio-organic Chemistry, University Joseph Fourier / CEA Grenoble, in the group of Dr Marinella Mazzanti(Grenoble, France).
  • 2004 : Master in Organic Chemistry, University Montpellier II (Montpellier, France).
  • 2004 : « Diplôme d’ingénieur Chimiste », ENSCM (Montpellier, France).


    Fundings

ANR JCJC (Agence Nationale de la Recherche & Alsace Biovalley, 2011-2014), Région Alsace & CNRS, 2011-2014).

Research interests

  • Design and synthesis of novel ligands for nuclear medical imaging
  • Synthesis and study of 64Cu radiolabeled nanomaterials for diagnostic and radiotherapy
  • Synthesis and study of luminescent coordination conjugates and luminescent nanoparticles for medical imaging
  • Design, synthesis and study of Gd(III) complexes for MRI

Keywords : medical imaging, lanthanide, copper, luminescence, MRI.

Bibliography

  • 2015 :

24. Radiometals : Towards a New Success Story in Nuclear Imaging ?
Brasse, D. ; Nonat, A. ; Dalton Trans. (Perspective). 2015, 44, 4845-4858.

23. Importance of outer sphere and aggregation phenomena in the relaxation properties of phosphonated gadolinium complexes with potential applications as MRI Contrast Agents
Elhabiri, M. ; Abada, S. ; Sy, M. ; Nonat A. ; Choquet, P. ; Esteban-Gomez, D. ; Cassino, C. ; Platas-iglesias, C. ; Botta, M. ; Charbonnière, L. J. Chem. Eur. J., 2015, 21, 6535.

22. Kinetically inert bispidol-based Cu(II) chelate for 64/67Cu nuclear medicine and diagnosis
Roux, A. ; Nonat, A.M. ; Brandel, J. ; Hubscher, V. ; Charbonnière, L.J. Inorg. Chem. 2015, 54, 4431-4444.

  • 2014 :

21. Supramolecular Luminescent Lanthanide Dimers for Fluoride Sequestering and Sensing
Liu, T. ; Nonat A. ; Beyler M. ; Regueiro-Figueroa M. ; Nchimi Nono K. ; Jeannin, O. ; Camerel, F ; Debaene, F ; Cianférani-Sanglier S. ; Tripier, R ; Platas-Iglesias, C ; and Charbonnière, L.J. Angew. Chem. Int. Ed. 2014, 53, 7259-7263.

20. Thin-coated water soluble CdTeS alloyed quantum dots as energy donors for highly efficient FRET
Yahia-Ammar, A. ; Nonat, A. M. ; Boos, A. ; Rehspringer, J.-L ; ; Asfari, Z. ; Charbonnière, L. J. ; Dalton Trans. 2014, 43, 15583-15592.

  • 2013 :

19. Syntheses, structural diversity and photo-physical properties of some pyridine-4-amidoxime based copper(I) and silver(I) polymers
Nandy, M. ; Banerjee, S. ; Rizzoli, C. ; Zangrando, E. ; Nonat, A. ; Charbonnière, L.J. ; Mitra S. to be published in Polyhedron (doi:10.1016/j.poly.2013.08.345).

18. Thermally stable luminescent zinc–Schiff base complexes : A thiocyanato bridged 1D coordination polymer and a supramolecular 1D polymer
Maiti, M. ; Thakurta, S. ; Sadhukhan, D. ; Pilet, G. ; Rosair, G.M. ; Nonat, A. ; Charbonnière, L.J. and Mitra, S. Polyhedron 2013, 65, 6-15.

17. Self-Aggregated Dinuclear Lanthanide(III) Complexes as Potential Bimodal Probes for Magnetic Resonance and Optical Imaging
Regueiro-Figueroa, M. ; Nonat, A. ; Rolla, G.A. ; Esteban-Gómez, D. ; de Blas, A. ; Rodríguez-Blas, T. ; Charbonnière, L.J. ; Botta, M. ; Platas-Iglesias, C. Chem. Eur. J. 2013, 19, 11696-11706.

16. Ln2M complexes (M = Ru, Re) derived from a bismacrocyclic ligand containing a 4,4’-dimethyl-2,2’-bipyridyl bridging unit
Charbonnière, L.J. ; Faulkner, S. ; Platas-Iglesias, C. ; Regueiro-Figueroa, M. ; Nonat, A. ; Rodríguez-Blas, T. ; de Blas, A. ; Perry W.S. ; Tropiano, M. Dalton Trans. 2013, 42, 3667-3681. (doi : 10.1039/c2dt32660d).

  • 2012 :

15. Definition of an intramolecular Eu to Eu energy transfer within a discrete [Eu2L] complex in solution
A. Nonat, M. Figueiro-Rigueroa, D. Esteban-Gómez, A. de Blas, T. Rodríguez-Blas, C. Platas-Iglesias, L.J. Charbonnière, Chem. Eur. J., 2012, 18, 8163-8173

14. A Series of Dicyanamide-Interlaced Assembly of Zinc-Schiff Base Complexes : Crystal Structure, Photophysical and Thermal Studies
M. Maiti, D. Sadhukhan, S. Thakurta, S. Roy, G. Pilet, R. J. Butcher, A. Nonat, L.J. Charbonnière, S. Mitra, Inorg. Chem., 2012, 51, 12176-12187

13. Bispidone-based ligands : Stereochemical control upon substitution
T. Legdali, A. Roux, A. M. Nonat, C. Platas-Iglesias, L. J. Charbonnière, J. Org. Chem., 2012, 77, 11167-11176

12. New Bisaqua Picolinate-Based Gadolinium Complexes as MRI Contrast Agents with Substantial High-Field Relaxivities
A. Nonat, C. Gateau, P.H. Fries, L. Helm, M. Mazzanti, Eur. J. Inorg. Chem., 2012, 12, 2049-2061

  • 2011 :

11. Cobalt(II), Manganese(IV) Mononuclear and Zinc(II) Symmetric Dinuclear Complexes of an Aliphatic Hydrazone Schiff Base Ligand with Diversity in Coordination Behaviors and Supramolecular Architectures : Syntheses, Structural Elucidations, and Spectroscopic Characterizations
D. Sadhukhan, A. Ray, G. Pilet, G. M. Rosair, E. Garribba, A. Nonat, L. J. Charbonnière, S. Mitra, Bull. Chem. Soc. Jpn., 2011, (7), 764-777

10. New Potential Bimodal Imaging Contrast Agents Based on DOTA-like and Porphyrin Macrocycles
C. P. Gros, A. Eggenspiller, A. Nonat, J.-M. Barbe, F. Denat, Med. Chem. Commun., 2011, (2), 119-125

  • 2010 and before :

9. Mixed d-f(3) Coordination Complexes Possessing Improved Near-Infrared (NIR) Lanthanide Luminescent Properties in Aqueous Solution
A. M. Nonat, C. Allain, S. Faulkner, T. Gunnlaugssoon, Inorg. Chem., 2010, (49), 8449 -8456

8. Water Stability and Luminescence of Lanthanide Complexes of Tripodal Ligands Derived from 1,4,7-triazacyclononane : pyridine carboxamide versus picolinate donors
G. Nocton, A. Nonat, D. Imbert, C. Gateau, M. Mazzanti, Helv. Chim. Acta, 2009, (92), 2257-2273

7. Gadolinium(III) Complexes of 1,4,7-triazacyclononane Based Picolinate Ligands : Simultaneous Optimization of Water Exchange Kinetics and Electronic Relaxation
A. Nonat, M. Giraud, C. Gateau, P. H. Fries, L. Helm, M. Mazzanti, Dalton Trans., 2009, (38), 8033-8046

6. Exploring the Luminescent Sensing and Self-assembly Formation of mixed f-d Metal Ion Complexes between Eu(III)-cyclen-phen conjugates and Cu(II), Fe(II), and Co(II) in Aqueous Buffered Solution
A. M. Nonat, A. J. Harte, K. Sénéchal-David, J. P. Leonard, T. Gunnlaugsson, Dalton Trans., 2009, (24), 4703 – 4711

5. Mixed f−d Coordination Complexes as Dual Visible- and Near-Infrared-Emitting Probes for Targeting DNA
A. M. Nonat, S. J. Quinn, K., T. Gunnlaugsson, Inorg. Chem., 2009, 48(11), 4646–4648

4. Structural and Photophysical Studies of High Stability Lanthanide Complexes of Tripodal 8-hydroxyquinolinate Ligands Based on 1,4,7-Triazacyclononane
A. M. Nonat, M. Giraud, D. Imbert, J. Pécaut, M. Mazzanti, Inorg. Chem., 2009, 48(9), 4207-4218

3. Multiple-frequency EPR spectra of two aqueous Gd3+ polyaminopolypyridine carboxylate complexes : a study of high field effects
A. Borel, S. Laus, A. Ozarowski, C. Gateau, A. Nonat, M. Mazzanti, L. Helm, J. Phys. Chem., 2007, 111(25), 5399-5407

2. Structure, Stability, Dynamics, High-Field Relaxivity, and Ternary Complex Formation of a New Tris(aquo) Gadolinium Complex
A. Nonat, P. H. Fries, J. Pécaut, M. Mazzanti, Chem. Eur. J., 2007, (13), 8489-8506

1. Lanthanide complexes of a picolinate ligand derived from 1,4,7-triazacyclononane with potential application in Magnetic Resonance Imaging and Time-Resolved Luminescence Imaging
A. Nonat, C. Gateau, P. H. Fries, M. Mazzanti, Chem. Eur. J., 2006, (12), 7133-7150

Patent : Novel lanthanide ligands and complexes, and use thereof as contrast agents
M. Mazzanti, C. Gateau, A. Nonat, PCT Int. Appl., 2007, 40pp, WO 2007083036