Département Ecologie, Physiologie et Ethologie
IPHC - UMR 7178, CNRS-UDS
23 rue Becquerel
67087 Strasbourg Cedex 2
Tel : +22.214.171.124.69.29
Fax : +33.3. 88.10.69.06
e-mail : fabielle.angel(at)iphc.cnrs.fr
Participation à la Formation
* Enseignant en Ecole Nationale Supérieure D’Ingénieur (option applications biomédicales : physiologie humaine) et enseignement en alternance « FIC Santé », ENSPS Strasbourg, depuis 2000.
Administration de la Recherche
Présidente du Comité d’Ethique Régional en Expérimentation Animale de Strasbourg (CREMEAS), depuis juin 2005
Physiopathology of the brain-gut axis
The interactions between the periphery and the brain are controlled through somatomotor, autonomic, and neurohumoral pathways involved in energy intake, expenditure and storage. The gastrointestinal tract plays a major role in this context. Understanding the brain-gut interplay motivated some historical physiological researches that still continued and provided discoveries until recently using experiments on lower animals. The animal model used in the present study was the neonatal lesion of the ventral hippocampus (NVHL) in rats. It was currently used to illustrate the neurodevelopmental hypothesis of schizophrenia. It consists in causing hippocampal damage at the end of the first week of life. The lesion indirectly elicits some modifications in brain development which are regarded as crucial for the validity of this model especially because its main effects were reversed with neuroleptic drugs. Relevant for the purpose of the present research is the observation of body weight perturbations in such rats. NVHL rats exhibited enhanced appetitive responses to food but with no consequences in terms of body weight. But, several authors reported that NVHL rats lost weight. By analogy to what was found in patients, we postulated that this could reflect a modification of the management of the peripheral functions by the central nervous system through the hypothalamic-pituitary-adrenal axis and vagal nerves or an expansion of the neuro-developmental disorder produced by the lesion to the autonomic nervous system.