DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]FNa

sodium [18F]fluoride

Chemical structure of [18F]FNa

Biology:

Biological test:Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Hydroxyapatite matrix
Related Genes:
Pathologies:Bone diseases
Cancer (undefined subtype)
Biological models:Human
Mouse
Rabbit
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Undefined

Selected references:

"Whole-body skeletal imaging in mice utilizing microPET: optimization of reproducibility and applications in animal models of bone disease", Eur. J. Nucl. Med., 2002, 29(9), 1225-1236

"Skeletal PET with 18F-Fluoride: Applying New Technology to an Old Tracer", J. Nucl. Med., 2008, 49(1), 68-78

"An efficient and aseptic preparation of "sodium fluoride (18F) injection" in a GMP compliant facility", Ann. Nucl. Med., 2010, 24, 149-155

"An automated method for preparation of [18F]sodium fluoride for injection, USP to address the technetium-99m isotope shortage", Appl. Rad. Isot., 2010, 68, 117-119

"Prospective Evaluation of 99mTc MDP Scintigraphy, 18F NaF PET/CT, and 18F FDG PET/CT for Detection of Skeletal Metastases", Mol. Imaging Biol., 2012, 14, 252-259


Biology and chemistry notes:

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- contact : dirac@iphc.cnrs.fr -