DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]FHBG

9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine

Chemical structure of [18F]FHBG

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:HSV1-tk
Related Genes:HSV-tk
Pathologies:Imaging gene expression
Stem Cell Labelling
Biological models:Human
Mouse
Pig
Primate NH
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Guanine derivatives
Nucleic base derivatives

Selected references:

"A simplified one-pot synthesis of 9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) and 9-(4-[18F]Fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy", Nucl. Med. Biol., 2001, 28, 875-883

"Human Pharmacokinetic and Dosimetry Studies of [18F]FHBG: A Reporter Probe for Imaging Herpes Simplex Virus Type-1 Thymidine Kinase Reporter Gene Expression", J. Nucl. Med., 2001, 42, 1225-1234

"Positron emission Tomography Imaging of Cardiac Reporter Gene Expression in Living Rats", Circulation, 2002, 106, 180-183

"Positron-Emission Tomography Reporter Gene Expression Imaging in Rat Myocardium", Circulation, 2003, 107, 326-332

"Rapid and reproducible radiosynthesis of [18F]FHBG", Nucl. Med. Biol., 2004, 31, 133-138

"A Tracer Kinetic Model for 18F-FHBG for Quantitating Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Expression in Living Animals Using PET", J. Nucl. Med., 2004, 45, 1560-1570

"A high yield robotic synthesis of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]-fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) for gene expression", Appl. Rad. Isot., 2007, 65, 57-63

"Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardium", Mol. Imaging Biol., 2009, 11, 408-414

"Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes", Antiviral Res., 2010, 88, 129-142

"Evaluation of an automated double-synthesis module: efficiency and reliability of subsequent radiosyntheses of FHBG and FLT", Nucl. Med. Biol., 2011, 39, 586-592


Biology and chemistry notes:

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