DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

FMISO

Fluoromisonidazole

1-(2'-nitro-1'-imidazolyl)-3-[18F]fluoro-2-propranol

Chemical structure of FMISO

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Hypoxia marker
Related Genes:
Pathologies:Cancer (undefined subtype)
Cardiology
Biological models:Dog
Human
Mouse
Pig
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Nitro Imidazol derivatives

Selected references:

"A Radiosynthesis of fluorine- 18 Fluoromisonidazole", J. Nucl. Med., 1989, 30, 343-350

"Assessment of Hypoxia and Perfusion in Human Brain Tumors Using PET with 18F-Fluoromisonidazole and 15O-H2O", J. Nucl. Med., 2004, 45, 1851-1859

"Fully automated one-pot synthesis of [18F]fluoromisonidazole", Nucl. Med. Biol., 2005, 32, 553-558

"Fully automated synthesis of [18F]fluoromisonidazole using a conventional [18F]FDG module", Nucl. Med. Biol., 2005, 32, 899-905

"Hypoxia Positron Emission Tomography Imaging With 18F-Fluoromisonidazole", Semin. Nucl. Med., 2007, 37, 451-461

"Pharmacokinetic Analysis of Hypoxia 18F-Fluoromisonidazole Dynamic PET in Head and Neck Cancer", J. Nucl. Med., 2010, 51, 37-45


Biology and chemistry notes:

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