DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]FET

O-(2-[18F]fluoroethyl)-L-tyrosine

Chemical structure of [18F]FET

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Amino Acids transporters (subtype L)
Related Genes:SLC43A1  /  SLC43A2
Pathologies:Brain Tumor
Biological models:Human
Mouse
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:(2-[18F]fluoroethoxy)phenyl
Amino Acids
Phenetylamine

Selected references:

"Synthesis and Radiopharmacology of O-(2-[18F]fluoroethyl)-L-Tyrosine for Tumor Imaging", J. Nucl. Med., 1999, 40, 205-212

"O-(2-[18F]fluoroethyl)-L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas", Brain, 2005, 128, 678-687

"O-(2-[18F]fluoroethyl)-L-Tyrosine: uptake mechanisms and clinical applications", Nucl. Med. Biol., 2006, 33, 287-294

"Prognostic Value of O-(2-18F-Fluoroethyl)-L-Tyrosine PET and MRI in Low-Grade Glioma", J. Nucl. Med., 2007, 48, 519-527

"Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine and its biological evaluation in B16 melanoma-bearing mice as PET tracer for tumor imaging", Sci. China Ser. B-chem., 2007, 50(2), 276-283

"Comparison of O-(2-18F-Fluoroethyl)-L-Tyrosine and L-3H-Methionine Uptake in cerebral hematomas", J. Nucl. Med., 2010, 51, 790-797

"Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the diagnosis of Glioblastoma", Arch. Neurol., 2010, 67(3), 370-372

"Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine based on a cartridge purification method", Nucl. Med. Biol., 2011, 38, 653-658

"Prognostic impact of postoperative, pre-irradiation 18F-fluoroethyl-L-tyrosine uptake in glioblastoma patients treated with radiochemotherapy", Radiother. Oncol., 2011, 99, 218-224

"Performance of 18F-Fluoro-Ethyl-Tyrosine (18F-FET) PET for the Differential Diagnosis of Primary Brain Tumor: A Systematic Review and Metaanalysis", J. Nucl. Med., 2012, 53, 207-214


Biology and chemistry notes:

For the D isomer see: Eur. J. Nucl. Med. Mol. Imaging 2006, 33, 1017-1024
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