DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]FACBC

[18F]-Fluciclovine

1-amino-3-[18F]-fluorocyclobutane-1-carboxylic acid

Chemical structure of [18F]FACBC

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Amino Acids transporters (subtype L)
Related Genes:SLC43A1  /  SLC43A2
Pathologies:Brain Tumor
Cancer (prostate)
Biological models:Human
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Amino Acids
Cyclobutane derivatives

Selected references:

"Improved synthesis of anti-[18F]FACBC: improved preparation of labeling precursor and automated radiosynthesis", Appl. Rad. Isot., 2003, 58, 657-666

"A Preliminary Study of Anti-1-Amino-3-[18F]-Fluorocyclobutyl-1-Carboxylic Acid for the detection of Prostate Cancer", J. Nucl. Med., 2007, 48, 46-55

"Initial Experience with the Radiotracer Anti-1-Amino-3-[18F]-Fluorocyclobutane-1-Carboxylic Acid with PET/CT in Prostate Carcinoma", J. Nucl. Med., 2007, 48, 56-63

"Biodistribution and Radiation Dosimetry of the Synthetic Nonmetabolized Amino Acid Analoguee Anti-[18F]-FACBC in Humans", J. Nucl. Med., 2007, 48, 1017-1020

"Initial Experience with the Radiotracer Anti-1-amino-3-[18F]fluorocyclobutane-1-Carboxylic Acid (Anti-[18F]FACBC) with PET in Renal Carcinoma", Mol. Imaging Biol., 2009, 11, 434-438

"Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-[18F]-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer", J. Nucl. Med., 2011, 52(5), 822-829


Biology and chemistry notes:

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