DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]ML-10

IBA Aposense

2-(5-[18F]-fluoro-pentyl)-2-methyl malonic acid

Chemical structure of [18F]ML-10

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Apoptotic cells
Related Genes:
Pathologies:Cancer (undefined subtype)
Biological models:Human
Mouse
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Carboxylic acid

Selected references:

"Molecular Imaging of Neurovascular Cell Death in Experimental Cerebral Stroke by PET", J. Nucl. Med., 2008, 49(9), 1520-1528

"Apoptosis imaging with PET-18F-ML-10 for early assessment of response of brain metastases to radiotherapy", J. Nucl. Med., 2009, 50(S), 453-453

"Small-Molecule Biomarkers for Clinical PET Imaging of Apoptosis", J. Nucl. Med., 2010, 51(6), 837-840

"Fully automated synthesis of apoptosis probe PET 18F-ML-10 with a multipurpose chemistry platform", J. Nucl. Med., 2010, 51(S), 588-588

"18F-ML-10, a PET Tracer for Apoptosis: First Human Study", J. Nucl. Med., 2011, 52(5), 720-725

"Automated Radiosynthesis of [18F]ML-10, a PET Radiotracer Dedicated to Apoptosis Imaging, on a TRACERLab FX-FN Module", Mol. Imaging Biol., 2012, 15(1), 12-18

"Microfluidic radiosynthesis and biodistribution of [18F] 2-(5-fluoro-pentyl)-2- methyl malonic acid", J. Label. Compd. Radiopharm., 2013, 56, 289-294


Biology and chemistry notes:

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