DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure




Chemical structure of [18F]FCH


Biological test:Cellular
PET Imaging
Development level:Clinical
Biological targets:Choline kinase
Choline Transporters
Related Genes:CHKA  /  CHKB  /  SLC44A1  /  SLC44A2  /  SLC5A7
Pathologies:Cancer (prostate)
Biological models:Human


Automated radiosynthesis :Yes
Structure type:Ammonium
Choline derivatives

Selected references:

"Synthesis and Evaluation of 18F-labeled Choline as an Oncologic Tracer for Positron Emission Tomography: Initial Findings in Prostate Cancer", Cancer Res., 2000, 61, 110-117

"Synthesis and Evaluation of 18F-Labeled Choline Analogs as Oncologic PET Tracers", J. Nucl. Med., 2001, 42(12), 1805-1814

"[18F]fluorocholine PET/CT imaging for the detection of recurrent prostate cancer at PSA relapse: experience in 100 consecutive patients", Eur. J. Nucl. Med. Mol. Imaging, 2006, 33(12), 1387-1398

"Localization of Primary Prostate Cancer with Dual-Phase 18F-Fluorocholine PET", J. Nucl. Med., 2006, 47(2), 262-269

"Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 Gliomas and Correlation with 131I-SIP(L19), a Marker of Angiogenesis", J. Nucl. Med., 2007, 48(4), 608-614

"Fully automated [18F]fluorocholine synthesis in the TracerLab MXFDG Coincidence synthesizer", Nucl. Med. Biol., 2008, 35, 255-260

"Fully automated preparation of [11C]choline and [18F]fluoromethylcholine using TracerLab synthesis modules and facilitated quality control using analytical HPLC", Appl. Rad. Isot., 2011, 69, 403-409

"18F-fluorocholine for prostate cancer imaging: a systematic review of the literature", Prostate Cancer P. D., 2012, 15, 45-55

"A fully-automated one-pot synthesis of [18F]fluoromethylcholine with reduced dimethylaminoethanol contamination via [18F] fluoromethyl tosylate", Appl. Rad. Isot., 2013, 78, 26-32

Biology and chemistry notes:

This one is the "Real FluoroCholine"
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- contact : dirac@iphc.cnrs.fr -