DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

[18F]FAZA

[18F]fluoro-azomycinarabino-furanoside

Chemical structure of [18F]FAZA

Biology:

Biological test:Cellular
Bio-distribution
PET Imaging
Development level:Clinical
Biological targets:HIF 1alpha
Hypoxia marker
Related Genes:HIF1A  /  HIF1AN  /  HIF1AP1
Pathologies:Cancer (undefined subtype)
Biological models:Human
Mouse
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Nitro Imidazol derivatives
Sugar

Selected references:

"[18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): A comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors", Nucl. Med. Biol., 2003, 30, 317-326

"Hypoxia-Specific Tumor Imaging with 18F-Fluoroazomycin Arabinoside", J. Nucl. Med., 2005, 46(1), 106-113

"Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA - first small animal PET results", J. Pharm. Pharmaceut. Sci., 2007, 10(2), 203-211

"Pretreatment 18F-FAZA PET Predicts Success of Hypoxia-Directed Radiochemotherapy Using Tirapazamine", J. Nucl. Med., 2007, 48(6), 973-980

"IMAGING HYPOXIA IN XENOGRAFTED AND MURINE TUMORS WITH 18F-FLUOROAZOMYCIN ARABINOSIDE: A COMPARATIVE STUDY INVOLVING MICROPET, AUTORADIOGRAPHY, PO2-POLAROGRAPHY, AND FLUORESCENCE MICROSCOPY", Int. J. Radiation Oncology Biol. Phys., 2008, 70(4), 1202-1212

"Initial results of hypoxia imaging using 1-α-D-(5-deoxy-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole (18F-FAZA)", Eur. J. Nucl. Med. Mol. Imaging, 2009, 36, 1565-1573

"Significant impact of different oxygen breathing conditions on noninvasive in vivo tumor-hypoxia imaging using [18F]-fluoro-azomycinarabino-furanoside ([18F]FAZA)", Radiat. Oncol., 2011, 6(165), 1-10

"High-yield automated synthesis of [18F]fluoroazomycin arabinoside ([18F]FAZA) for hypoxia-specific tumor imaging", Appl. Rad. Isot., 2011, 69, 1007-1013

"FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial", Radiother. Oncol., 2012, 105(1), 14-20

"PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice", Eur. J. Nucl. Med. Mol. Imaging, 2013, 40, 186-197


Biology and chemistry notes:

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