DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

FLT

[18F]fluorothymidine

3'-deoxy-3'-[18F]fluorothymidine

Chemical structure of FLT

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Thymidine kinase-1
Related Genes:TK1
Pathologies:Cell proliferation
Biological models:Dog
Human
Mouse
Primate NH
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Nucleic base derivatives
Sugar
Thymine derivatives

Selected references:

"Radiosynthesis of 3'-Deoxy-3'-[18F]fluorothymidine: [18F]FLT for Imaging of Cellular Proliferation In Vivo", Nucl. Med. Biol., 2000, 27, 143-156

"3'-[18F]Fluoro-3'-Deoxythymidine ([18F]-FLT) as Positron Tomography Tracer for Imaging Proliferation in a Murine B-Cell Lymphoma Model and in the Human Disease", Cancer Res., 2003, 63, 2681-2687

"Fully automated synthesis system of 3'-deoxy-3'-[18F]fluorothymidine", Nucl. Med. Biol., 2004, 31, 803-809

"FLT: Measuring Tumor Cell Proliferation In Vivo With Positron Emission Tomography and 3'-Deoxy-3'-[18F]Fluorothymidine", RemiÓ. Jucl. Med., 2007, 37, 429-439

"Comparison of 18F-FDG, 18F-FET and 18F-FLT for differentiation between tumor and inflammation in rats", Nucl. Med. Biol., 2009, 36, 681-686

"A facile and rapid automated synthesis of 3'-deoxy-3'-[18F]fluorothymidine", Appl. Rad. Isot., 2010, 68, 1734-1739

"Highlighting the versatility of the tracerlab synthesis modules. Part 1: fully automated production of [18F]labelled radiopharmaceuticals using a Tracerlab FXFN", J. Label. Compd. Radiopharm., 2011, 54, 292-307


Biology and chemistry notes:

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