DIRAC - 18F-Database of Imaging RAdiolabelled Compounds

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Names: Chemical Structure

FDG

2'-[18F]fluoro-2'-Deoxy-glucose

fluorodeoxyglucose

Chemical structure of FDG

Biology:

Biological test:Cellular
Bio-distribution
Metabolism
PET Imaging
Development level:Clinical
Biological targets:Glucose metabolism
Hexokinase
Related Genes:HK1  /  HK2
Pathologies:Cancer (undefined subtype)
Cardiology
Other Neurologic Diseases
Biological models:Human
Mouse
Pig
Primate NH
Rat

Chemistry:

Automated radiosynthesis :Yes
Structure type:Sugar

Selected references:

"The rate-limiting step for tumor [18F]fluoro-2-deoxy-D-glucose (FDG) Incorporation", Nucl. Med. Biol., 2001, 28, 1-4

"Review of 18F-FDG synthesis and quality control", Biomed. Imaging Interv. J., 2006, 2(4), 1-11

"Clinical use of FDG PET", Nucl. Med. Biol., 2007, 34, 737-742

"Recommendations on the Use of 18F-FDG PET in Oncology", J. Nucl. Med., 2008, 49, 480-508

"Assessment of radionucleic impurities in 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) routine production", Appl. Rad. Isot., 2008, 66, 295-302

"A simple Method for the quality control of [18F]FDG", Appl. Rad. Isot., 2010, 68, 1740-1742


Biology and chemistry notes:

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