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DEPE | Séminaires BEEPSS / BEEPSS Seminars » The pleiotropic role of mitochondrial uncoupling in comparative physiology (...)

The pleiotropic role of mitochondrial uncoupling in comparative physiology and evolution

Last update: : Monday 9 November 2015, by Nicolas Busser

Par : Martin Jastroch, Helmholtz Institute, Munich, Germany
Date : Jeudi 10 décembre 2015 à 13h30
Lieu : Amphithéâtre Marguerite Perey - Bâtiment 01

Abstract: Mitochondria are central to the conversion of nutrient to cellular energy, thus controlling systemic metabolism in animals. Niche expansion and species diversification led to special adjustments of mitochondria to cope with the environment, climate and physiological needs. In the past ten years, we studied the evolution of mitochondrial proton leak; a process that allows to combust nutrient energy as heat in mitochondria. This enables ectothermic vertebrates to adjust ATP production to environmental challenges. In mammals, a major role of proton leak evolved in adipose tissue and was geared towards heat production to maintain endothermy. The understanding of the evolution and mechanisms of proton leak, as well as its systemic regulation, opens a new window to understand the underlying molecular strategies for ecological and physiological adaptation in animals.