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DEPE | Séminaires BEEPSS / BEEPSS Seminars » Mechanisms of muscle maintenance in hibernating brown bears

Mechanisms of muscle maintenance in hibernating brown bears

Last update: : Friday 27 September 2019, by Nicolas Busser

Presented by: Fabrice Bertile, IPHC-DSA
Date: Thursday 28th November 2019, 13:00-14:30
Place: Amphithéàtre Grünewald, Bâtiment 25

Pluridisciplinary BEEPS

Hibernation has evolved in a variety of species as an adaptive strategy to survive harsh winter environmental conditions. It is a prolonged period of fasting, characterized by decreases in metabolic rates, physical activity, and body temperature. Hibernators generally are resistant to muscle loss despite months of inactivity and starvation, which suggest that hibernation can help finding new levers to fight human muscle atrophy, a main public health problem nowadays. To gain insights into protein sparing strategies, we examine metabolic networks in hibernating versus summer-active Scandinavian brown bear tissues. We also investigate how bear protein sparing strategies could be transferred to the human and help fight muscle atrophy.

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