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Séminaire présenté par Jochen Krimmer, IPN Lyon

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Online monitoring of the ion range during hadrontherapy by means of prompt radiation

Par : Jochen Krimmer, IPN Lyon
Date : vendredi 15 mars 2013 à 10h30
Lieu : IPHC, Salle de Réunion 2e étage du Bâtiment 27

Résumé :

The treatment of tumours by a beam of carbon ions or protons is an emerging method for cancer therapy. One of the advantages of this method is the fact that the ions deposit a large quantity of their dose at the end of their path in the Bragg Peak which allows a maximization of the dose applied to the tumor and a minimization of the dose hitting healthy tissue. To exploit the ballistic qualities of this method at its best, it is necessary to monitor the ion track inside the patient online, i.e. during the treatment.

Several concepts of nuclear imaging methods providing an online control during hadrontherapy are developed in the group CAS-PHABIO at IPNL Lyon. All these methods rely on the detection of secondary prompt radiation emitted after nuclear reactions of the incident ions.

Prompt gamma detection :

It has been shown that the production rate of prompt gammas is highly correlated to the dose deposited by the incident ions [1], [2]. The position of the Bragg peak can be determined via a detection of the fall off in the production rate of the prompt gammas.

Two systems for prompt gamma detection are currently under development, a camera with passive collimation and a Compton camera. The latter comprises a stack of silicon strip detectors and an absorber. This configuration allows the reconstruction of the incident photon direction via application of Compton kinematics.

Proton Interaction Vertex Imaging (pIVI) :

During carbon ion therapy secondary protons, coming from fragmentation of the projectile, carry information about the ion range, even in the case of deep-seated tumors, where the escaping protons are traversing more than 10 cm of patient tissue [3].

Within a common project with IPHC Strasbourg (QuapIVI) the applicability of pIVI for quality control during carbon ion treatment is being explored in terms of instrumentation and simulations.

The status of the development for the different systems will be given together with a presentation of results from different in-beam tests at various clinical and research facilities.

Personne à contacter : Kamila SIEJA

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[1C.H. Min et al. Appl. Phys. Lett. 89 (2006) 183517

[2E. Testa et al. Appl. Phys. Lett. 93 (2008) 093506

[3P. Henriquet et al., Phys. Med. Biol. 57 (2012) 4655-4669